Ultimate Cattle Drive Casserole–an easy family-friendly casserole made with a buttery biscuit crust, seasoned ground beef, fire-roasted tomatoes, green chiles and a creamy cheesy topping.

Cheesy Taco Biscuit Bake
This casserole is a fun change of pace. It starts with a biscuit crust and then you pile on a flavorful taco-style beef mixture with fire-roasted tomatoes and green chiles. The next layer is a creamy topping made with mayonnaise, sour cream, and Greek yogurt and finally it’s topped with shredded sharp cheddar cheese. I love how easy this is to throw together on a busy night. The whole family was home plus one of Skyler’s friends and we ate the entire pan. Enjoy!
Ingredients/Substitution Ideas
- Pillsbury biscuits
- Lean ground beef–or ground turkey
- Onion–or shallot
- Kosher salt
- Black pepper
- Garlic powder–or 1 Tbsp minced garlic
- Onion powder
- Chili powder
- Cumin
- Dried oregano
- Fire roasted tomatoes–or diced tomatoes
- Diced green chiles
- Mayonnaise
- Sour cream
- Greek yogurt
- Shredded cheddar cheese–or Monterey Jack cheese
Steps
Heat oven to 375° F. Spray a 9×13 inch pan with non stick cooking spray. Open the biscuits and press them into the bottom of the pan to make a crust. Bake for 10 minutes. Set aside.


Heat a pan over medium high heat. Add in the beef and break it up. Add in the onions. Brown for 5 minutes. Drain off excess grease. Stir in the salt, pepper, garlic powder, onion powder, chili powder, cumin and oregano. Stir in the tomatoes and green chiles and bring to a simmer. Pour the mixture over the biscuits.

In a bowl whisk together the mayo, sour cream and yogurt. Drop it by dollops over the top of the meat mixture.

Sprinkle the cheddar on top. Bake for 30 minutes.

Let it sit for 5 minutes before slicing and serving.

Notes/Tips
- Serve with a green salad or some steamed green beans.
- If your ground beef releases a lot of grease, drain it well before adding the tomatoes.
- Add a handful of corn or black beans to the meat mixture if you want to stretch the casserole further.
- Store leftovers in an airtight container* in the refrigerator for up to 4 days. This casserole can be frozen after baking. Cool completely, wrap tightly, and freeze for up to 2 months. Thaw overnight in the refrigerator before reheating.
- Other recipes you can make with Greek yogurt are Kentucky Chicken Casserole and Okey Dokey Chicken.
Did you know you can filter the recipes on my website to search by meat type, IP or Crockpot, low carb, gluten free, etc.? Use the filter to find exactly what you are looking for.


Ultimate Cattle Drive Casserole
- Prep Time: 25 minutes
- Cook Time: 30 minutes
- Total Time: 55 minutes
- Yield: 6 1x
Description
An easy family-friendly casserole made with a buttery biscuit crust, seasoned ground beef, fire-roasted tomatoes, green chiles and a creamy cheesy topping.
Ingredients
- 12 oz package Pillsbury biscuits
- 16 oz lean ground beef
- 1 cup diced onion
- 1 tsp kosher salt
- 1 tsp black pepper
- 1 tsp garlic powder
- 1 tsp onion powder
- 2 tsp chili powder
- 1 tsp cumin
- 1/4 tsp dried oregano
- 1 (14.5 oz) can fire roasted tomatoes
- 1 (4 oz) can diced green chiles
- 1/4 cup mayonnaise
- 1/4 cup sour cream
- 1/4 cup Greek yogurt
- 1 1/2 cups shredded cheddar cheese
Instructions
- Heat oven to 375° F. Spray a 9×13 inch pan with non stick cooking spray. Open the biscuits and press them into the bottom of the pan to make a crust. Bake for 10 minutes. Set aside.
- Heat a pan over medium high heat. Add in the beef and break it up. Add in the onions. Brown for 5 minutes. Drain off excess grease. Stir in the salt, pepper, garlic powder, onion powder, chili powder, cumin and oregano. Stir in the tomatoes and green chiles and bring to a simmer. Pour the mixture over the biscuits.
- In a bowl whisk together the mayo, sour cream and yogurt. Drop it by dollops over the top of the meat mixture. Sprinkle the cheddar on top.
- Bake for 30 minutes.
- Let it sit for 5 minutes before slicing and serving.
- Category: Beef
- Method: Stove and Oven

More beef casseroles…
Lancaster County Amish Cheeseburger Casserole
A savory breakfast casserole with ground beef, pickles, and French bread cubes baked in an egg and milk custard, a cheeseburger twist on the classic morning dish.
Blue Collar Belly Warmer
A layered dish with creamy mashed potatoes on the bottom, savory beef and gravy in the middle, melty cheddar in between, and golden biscuit bites on top.
Fat Boy Casserole
An easy, hearty tater tot casserole made with seasoned ground beef, a creamy sauce, and melted cheddar cheese. A classic dish and one satisfying family dinner.
*Karen Petersen is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com.




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