Duke’s Casserole–a layer of biscuits topped with taco meat, tomatoes, jalapenos, sour cream and cheese.

Duke’s Casserole
Oh my gosh, you have to try making Duke’s Casserole for dinner this week! It’s one of those hearty, feel-good dishes that checks all the boxes for comfort food. The combination of ground beef with zesty taco seasoning, creamy sour cream, and a buttery biscuit base just comes together so perfectly. The layers of flavors are seriously amazing, from the savory meat and pickled jalapenos to the melty, cheesy top—it’s a total flavor bomb. Plus, it’s super easy to make, which is a major win for weeknight dinners. You basically just layer everything in a baking dish and let the oven do its magic. Even picky eaters tend to love it, and it makes fantastic leftovers.
Ingredients/Substitution Ideas
- Pillsbury buttermilk biscuits
- Lean ground beef–I used 93/7
- Kosher salt
- Black pepper
- Garlic powder
- Onion powder
- Cumin
- Chili powder
- Smoked paprika
- Sour cream
- Mayonnaise
- Garlic salt
- Fresh tomatoes–I used sliced grape tomatoes
- Pickled tame jalapenos–look for Mezzetta brand next to the pickles
- Sharp cheddar–or colby, monterey jack
Steps
Preheat oven to 350 degrees F. Spray a 9×13 inch baking dish with non-stick cooking spray.
Place biscuits into the pan in a single layer and press them into the pan, joining them together and covering the bottom of the pan as best as you can.

Bake for 12 minutes. The dough should be very light brown. Remove from the oven and set aside, leave the oven on.

Heat a medium pan over medium high heat. Add in the ground beef and break it up. Brown for 5 minutes, drain off excess grease. Stir in the salt, pepper, garlic powder, onion powder, cumin, chili powder and paprika. Set aside.

In a small bowl stir together the sour cream, mayo and garlic salt.
On the top of the biscuit crust, layer the ingredients as follows: ground beef, tomatoes, jalapenos, sour cream mixture and finally the cheese.



Bake for 30 minutes. Slice and serve.

Notes/Tips
- Serve with shredded lettuce and a side of seasoned black beans.
- Try adding in a diced onion with while you brown the ground beef. For even more veg add in some sliced bell peppers.
- If you don’t have fresh tomatoes you can use half a can of diced tomatoes.
- Try subbing sliced banana peppers for the jalapeno peppers.
- Store leftovers in an airtight container* in the refrigerator for up to 5 days or in the freezer for up to 3 months.
- Other recipes you can make with mayo are Roasted Salmon with Creamy Garlic Lemon Sauce and Grandpa’s Firehouse Chicken.
Did you know you can filter the recipes on my website to search by meat type, IP or Crockpot, low carb, gluten free, etc.? Use the filter to find exactly what you are looking for.


Duke’s Casserole
- Prep Time: 30 minutes
- Cook Time: 30 minutes
- Total Time: 60 minutes
- Yield: 8 servings 1x
Description
A layer of biscuits topped with taco meat, tomatoes, jalapenos, sour cream and cheese.
Ingredients
- 1 (12 oz) package Pillsbury buttermilk biscuits
- 1 pound lean ground beef
- 1 tsp kosher salt
- 1 tsp black pepper
- 1 tsp garlic powder
- 1 tsp onion powder
- 1 tsp cumin
- 1 1/2 tsp chili powder
- Pinch of smoked paprika
- 1/2 cup sour cream
- 1/4 cup mayonnaise
- 1/4 tsp garlic salt
- 1/2 cup fresh tomatoes, diced
- 1/2 cup pickled tame jalapenos
- 1 cup shredded sharp cheddar
Instructions
- Preheat oven to 350 degrees F. Spray a 9×13 inch baking dish with non-stick cooking spray.
- Place biscuits into the pan in a single layer and press them into the pan, joining them together and covering the bottom of the pan as best as you can. Bake for 12 minutes. The dough should be very light brown. Remove from the oven and set aside, leave the oven on.
- Heat a medium pan over medium high heat. Add in the ground beef and break it up. Brown for 5 minutes, drain off excess grease. Stir in the salt, pepper, garlic powder, onion powder, cumin, chili powder and paprika. Set aside.
- In a small bowl stir together the sour cream, mayo and garlic salt.
- On the top of the biscuit crust, layer the ingredients as follows: ground beef, tomatoes, jalapenos, sour cream mixture and finally the cheese.
- Bake for 30 minutes. Slice and serve.
- Category: Beef
- Method: Stove and Oven

More recipes with biscuit dough…
Marble Mountain Chicken
Instant Pot or Crockpot chicken with biscuit dumplings and vegetables in a savory, creamy broth.
Instant Pot Runza Casserole
The casserole has seasoned ground beef, onions, cabbage, cheese and crescent rolls. It’s a delicious way to feed your family dinner tonight.
*Karen Petersen is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com.



what is a tame jalapeño?
a cross between a jalapeño and a bell pepper that have the flavor and texture of a jalapeño but with less heat.
where do you get it?
Look by the pickles